Triethylamine → HCID 11277533, compound

HRID 2217853Notes

Reaction equation

HRID 2217853 reaction equation
Br[C:2]1[C:11]([CH3:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[CH:13]1([CH2:19][NH2:20])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1.C(N(CC)CC)C.CN1CCC[C:30]1=[O:34]>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[CH:13]1([CH2:19][NH:20][C:30]([C:2]2[C:3]3[CH:4]=[CH:5][CH:6]=[N:7][C:8]=3[CH:9]=[CH:10][C:11]=2[CH3:12])=[O:34])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 13387N-methyl-2-pyrrolidoneHCID 76688CyclohexanemethylamineHCID 141173605-BroMo-6-Methylquinoline

Product 1

HCID 11277533HCID 11277533, compound

Reagents, catalysts & solvents 1

HCID 178418476HCID 178418476, compoundCatalyst

Procedure

Prepared according to the method of example 42, using 5-bromo-6-methylquinoline (prepared according to the method of Khimiya Geterotsiklicheskikh Soedinenii 1988, 8, 1084) (4.0 g), cyclohexanemethylamine (4.2 mL), triethylamine (2.4 mL), dichlorobis(triphenylphosphine)palladium(II) (1.6 g) in N-methylpyrrolidinone (40 mL) to afford the title compound (3.9 g)

Workup

  1. customPrepared
  2. customprepared

Sources & evidence

ORD record
ord-3c435494e1504168a3b224dfb834b3d0
Source dataset
uspto-grants-2008_08
Patent number
US07408065B2

Reaction notes

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