Ammonium Hydroxide → HCID 13123247, compound

HRID 2218094Notes

Reaction equation

HRID 2218094 reaction equation
CO[C:3]1[C:8]2[CH:9]=[N:10][S:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.FC1C(OC)=CC=CC=1[CH:15]=[O:16].[S].[NH4+].[OH-]>COCCO>[CH3:15][O:16][C:6]1[C:7]2[S:11][N:10]=[CH:9][C:8]=2[CH:3]=[CH:4][CH:5]=1

Participants

6

Reactant 4

HCID 14923Ammonium HydroxideHCID 37744632-Fluoro-3-methoxybenzaldehydeHCID 5362487SulfurHCID 193843524-Methoxybenzo[d]isothiazole

Product 1

HCID 13123247HCID 13123247, compoundYield 14%

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

A method similar to 4-methoxy-benzo[d]isothiazole using 2-fluoro-3-methoxy-benzaldehyde (410 mg, 2.66 mmol), sulfur (85 mg, 2.66 mmol), NH4OH (5 mL), and 2-methoxyethanol (5 mL) gave the title compound (60 mg, 14%); Mass spectrum (ion-spray): m/z=165.8 (m+1).

Sources & evidence

ORD record
ord-c38e9498c7e54fdcb532a93378c659e0
Source dataset
uspto-grants-2008_08
Patent number
US07410982B2

Reaction notes

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