Hydrochloric Acid → HCID 10051520, compound

HRID 2218133Notes

Reaction equation

HRID 2218133 reaction equation
C[Si](C)(C)[O-].[K+].C([O:9][C:10](=[O:45])[CH2:11][N:12]([CH3:44])[C:13]1[CH:18]=[CH:17][C:16]([CH2:19][N:20]2[CH:25]=[CH:24][CH:23]=[C:22]([C:26]3[CH:31]=[CH:30][C:29]([NH:32][C:33]([NH:35][C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=4[CH3:42])=[O:34])=[CH:28][CH:27]=3)[C:21]2=[O:43])=[CH:15][CH:14]=1)C.Cl>O1CCCC1.C(OCC)C>[CH3:44][N:12]([CH2:11][C:10]([OH:45])=[O:9])[C:13]1[CH:18]=[CH:17][C:16]([CH2:19][N:20]2[CH:25]=[CH:24][CH:23]=[C:22]([C:26]3[CH:31]=[CH:30][C:29]([NH:32][C:33]([NH:35][C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=4[CH3:42])=[O:34])=[CH:28][CH:27]=3)[C:21]2=[O:43])=[CH:15][CH:14]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 23668039Potassium trimethylsilanolateHCID 59769588HCID 59769588, compound

Product 1

HCID 10051520HCID 10051520, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

Potassium trimethylsilanolate (0.035 g, 0.25 mmol) was added to a solution of [methyl-(4-{2-oxo-3-[4-(3-o-tolyl-ureido)phenyl]-2H-pyridin-1-ylmethyl}phenyl)amino]acetic acid ethyl ester (0.90 g, 0.17 mmol) in tetrahydrofuran (5 mL) and the mixture stirred at room temperature for 2 hours. A solution of hydrochloric acid in diethyl ether (1 M, 1 mL) was added and solvent evaporated. The residue was triturated with diethyl ether, filtered and dried to give the title compound as a solid.

Workup

  1. customsolvent evaporated
  2. customThe residue was triturated with diethyl ether
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-d2368dd157494d4db39de43e8534ecd5
Source dataset
uspto-grants-2008_08
Patent number
US07410984B2

Reaction notes

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