Water → HCID 178514300, compound

HRID 221986Notes

Reaction equation

HRID 221986 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[C:6]([N:18]=1)=[N:7][C:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[C:9]([OH:11])[N:10]=2.O.[NH2:20][NH2:21].CCOC(C)=O.O>O1CCOCC1>[NH:20]([C:2]1[CH:3]=[CH:4][C:5]2[C:6]([N:18]=1)=[N:7][C:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[C:9]([OH:11])[N:10]=2)[NH2:21]

Participants

6

Reactant 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 24654Hydrazine hydrate (1:1)HCID 178517175HCID 178517175, compound

Product 1

HCID 178514300HCID 178514300, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

6-chloro-3-phenylpyrido[2,3-b]pyrazin-2-ol (3-2) (26.2 g, 102 mmol) and hydrazine hydrate (26.2 g, 102 mmol) in 1,4-dioxane (400 mL) was stirred at 100° C. for 3 days. To the mixture was added EtOAc and water. The resulting solid was collected by filtration to give 6-hydrazino-3-phenylpyrido[2,3-b]pyrazin-2-ol (3-3) as yellow powder.

Workup

  1. filtrationThe resulting solid was collected by filtration

Sources & evidence

ORD record
ord-ebd1477e668f4b1eacd1b878364c16c7
Source dataset
uspto-grants-2012_06
Patent number
US08207169B2

Reaction notes

Loading…