Hydrochloric Acid → 1-Isopropyl-4-(3-methanesulfonyl-phenyl)-piperidine

HRID 2220080Notes

Reaction equation

[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH:8]=[CH:9][CH:10]=1)(=[O:4])=[O:3].[CH:17](Br)([CH3:19])[CH3:18].Cl>>[CH:17]([N:14]1[CH2:15][CH2:16][CH:11]([C:7]2[CH:8]=[CH:9][CH:10]=[C:5]([S:2]([CH3:1])(=[O:4])=[O:3])[CH:6]=2)[CH2:12][CH2:13]1)([CH3:19])[CH3:18]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 63582-Bromopropane

HCID 129889574-(3-(Methylsulfonyl)phenyl)piperidine

Product 1

HCID 223978431-Isopropyl-4-(3-methanesulfonyl-phenyl)-piperidine

Procedure

Beginning with 4-(3-methanesulfonyl-phenyl)piperidine and i-propylbromide: m.p. 220° C. (HCl); MS m/z (rel. intensity, 70 eV) 281 (M+, 4), 266 (bp), 187 (5), 129 (5), 115 (5)

Sources & evidence

ORD record: ord-f8c2f8b6e0ee44a8ac60001783f39070
Source dataset: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07417043B2

Reaction notes

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