1,2-Dibromoethane → 1-(2-Bromoethoxy)-4-iodobenzene

HRID 2220396Notes

Reaction equation

HRID 2220396 reaction equation
[I:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[Br:9][CH2:10][CH2:11]Br.C(=O)([O-])[O-].[K+].[K+]>>[Br:9][CH2:10][CH2:11][O:8][C:5]1[CH:6]=[CH:7][C:2]([I:1])=[CH:3][CH:4]=1

Participants

4

Reactant 3

HCID 78391,2-DibromoethaneHCID 108944-IodophenolHCID 11430Potassium Carbonate

Product 1

HCID 19058471-(2-Bromoethoxy)-4-iodobenzene

Procedure

The mixture of 4-iodophenol (6.0 g), 1,2-dibromoethane (26 ml) and potassium carbonate (5.28 g) was refluxed for 3 hours. The mixture was evaporated under reduced pressure. The residue was purified by column chromatography on silica gel (hexane/ethyl acetate=6/1) to give 1-(2-bromoethoxy)-4-iodobenzene (6.5 g).

Workup

  1. temperaturewas refluxed for 3 hours
  2. customThe mixture was evaporated under reduced pressure
  3. customThe residue was purified by column chromatography on silica gel (hexane/ethyl acetate=6/1)

Sources & evidence

ORD record
ord-438df0372305452ebf1db964cb700d8e
Source dataset
uspto-grants-2008_08
Patent number
US07417060B2

Reaction notes

Loading…