反应详情

Ethyl iodide (0.137 mL) was added to a suspension of methyl 4-benzyloxy-2-hydroxybenzoate (0.296 g) and potassium carbonate (0.317 g) in N,N-dimethylformamide (2.9 mL) at room temperature with stirring. The mixture was stirred at that temperature for 1.6 hrs and at 50° C. for 1.4 hrs. To the reaction mixture was added water, and the resulting mixture was extracted with ethyl acetate. The organic layer was washed with water, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford the title compound (0.293 g).

1. stirringThe mixture was stirred at that temperature for 1.6 hrs and at 50° C. for 1.4 hrs
2. extractionthe resulting mixture was extracted with ethyl acetate
3. washThe organic layer was washed with water
4. dry with materialdried over anhydrous magnesium sulfate
5. customThe solvent was evaporated under reduced pressure