反应详情

Ethyl iodide (0.268 mL) was added to a suspension of 4-benzyloxy-2-ethylbenzoic acid (0.572 g) and potassium carbonate (0.617 g) in N,N-dimethylformamide (5.6 mL) at room temperature with stirring. The mixture was stirred at 50° C. for 1.5 hrs and at room temperature for 13 hrs, and then water was added. The mixture was extracted with ethyl acetate. The organic layer was washed with water, an aqueous solution of sodium chloride and brine successively, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford the title compound (0.635 g).

1. stirringThe mixture was stirred at 50° C. for 1.5 hrs and at room temperature for 13 hrs
2. extractionThe mixture was extracted with ethyl acetate
3. washThe organic layer was washed with water
4. dry with materialan aqueous solution of sodium chloride and brine successively, and dried over anhydrous magnesium sulfate
5. customThe solvent was evaporated under reduced pressure