Hydrochloric Acid → HCID 69203504, compound

HRID 2220658Notes

Reaction equation

HRID 2220658 reaction equation
[OH:1][C@H:2]([C:27]1[CH:32]=[CH:31][C:30]([OH:33])=[C:29]([NH:34][S:35]([CH3:38])(=[O:37])=[O:36])[CH:28]=1)[CH2:3][NH:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:17][CH:16]=2)=[C:10]([CH3:26])[CH:9]=1.[ClH:39]>C(OCC)(=O)C>[ClH:39].[OH:1][C@H:2]([C:27]1[CH:32]=[CH:31][C:30]([OH:33])=[C:29]([NH:34][S:35]([CH3:38])(=[O:37])=[O:36])[CH:28]=1)[CH2:3][NH:4][CH2:5][CH2:6][O:7][C:8]1[CH:9]=[C:10]([CH3:26])[C:11]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:17][CH:16]=2)=[C:12]([CH3:14])[CH:13]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69202559HCID 69202559, compound

Product 1

HCID 69203504HCID 69203504, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

Ethyl 4′-{2-[(R)-2-hydroxy-2-(4-hydroxy-3-methanesulfonylaminophenyl)ethylamino]ethoxy}-2′,6′-dimethylbiphenyl-4-carboxylate was dissolved in ethyl acetate (4.3 mL), and a 4 mol/L solution of hydrogen chloride in ethyl acetate (0.2 mL) was added dropwise to the ice-cooled solution with stirring. The reaction mixture was concentrated in vacuo, and the residue was diluted with diethyl ether. The insoluble material was collected by filtration to afford the title compound (0.173 g).

Workup

  1. temperaturecooled solution
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. additionthe residue was diluted with diethyl ether
  4. filtrationThe insoluble material was collected by filtration

Sources & evidence

ORD record
ord-a70fed32928a4a3da75c01f8bb883cc4
Source dataset
uspto-grants-2008_08
Patent number
US07417169B2

Reaction notes

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