1-Naphthaldehyde → HCID 59772995, compound

HRID 2220692Notes

Reaction equation

HRID 2220692 reaction equation
[C:1]1([CH:11]=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[CH3:13][N:14]1[CH2:18][CH2:17][CH2:16][CH:15]1[CH2:19][CH2:20][NH2:21].[Na]>ClCCl>[CH3:13][N:14]1[CH2:18][CH2:17][CH2:16][CH:15]1[CH2:19][CH2:20][NH:21][CH2:11][C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 61951-NaphthaldehydeHCID 983882-(2-Aminoethyl)-1-methylpyrrolidineHCID 5360545Sodium

Product 1

HCID 59772995HCID 59772995, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Experimental condition analogous to Example 5, from 1-naphthalencarboxaldehyde 0.15 g (1 mmol), 2-(1-methyl-pyrrolidin-2-yl)-ethylamine 0.14 g (1.1 mmol), and sodium triacethoxyborohydride 0.31 g (1.5 mmol), in 10 mL dichloromethane. The crude material is 210 mg clear oil.

Sources & evidence

ORD record
ord-f1bd77258f484cd889301f69ec669b22
Source dataset
uspto-grants-2008_08
Patent number
US07417062B2

Reaction notes

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