Hydrochloric Acid → HCID 178524563, compound

HRID 2220730Notes

Reaction equation

HRID 2220730 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([NH:6][C:7]1[NH:11][N:10]=[C:9]([C:12]([O:14]C)=[O:13])[CH:8]=1)=[O:5].O[Li].O.O.Cl>C1COCC1.CO>[Cl:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([NH:6][C:7]1[NH:11][N:10]=[C:9]([C:12]([OH:14])=[O:13])[CH:8]=1)=[O:5]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 1784984355-(2-Chlorobenzoylamino)-3-methoxycarbonylpyrazole

Product 1

HCID 178524563HCID 178524563, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 1.0 eq. of 22 and 5.0 eq. of LiOH.H2O in THF, MeOH, and H2O (2:1:1) was stirred at rt. After a time sufficient for reaction completion, the reaction mixture was rotary evaporated. The mixture was acidified with concentrated HCl. As the pH of the solution reached about 2, a precipitate formed. The solid was collected by filtration and after drying under vacuum, product 23 was obtained.

Workup

  1. customAfter a time sufficient for reaction completion
  2. customa precipitate formed
  3. filtrationThe solid was collected by filtration
  4. customafter drying under vacuum

Sources & evidence

ORD record
ord-287c2dc85353442fac8e191772b4028d
Source dataset
uspto-grants-2008_08
Patent number
US07417152B2

Reaction notes

Loading…