2-Bromopropane → 1-(2-Chloro-5-pyridylmethyl)-3-isopropyl-2-nitroiminoimidazolidine

HRID 22219Notes

Reaction equation

HRID 22219 reaction equation
[H-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:11]2[CH2:15][CH2:14][NH:13][C:12]2=[N:16][N+:17]([O-:19])=[O:18])=[CH:6][N:5]=1.[H][H].[CH:22](Br)([CH3:24])[CH3:23]>CN(C)C=O>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:11]2[CH2:15][CH2:14][N:13]([CH:22]([CH3:24])[CH3:23])[C:12]2=[N:16][N+:17]([O-:19])=[O:18])=[CH:6][N:5]=1

Participants

6

Reactant 4

HCID 63582-BromopropaneHCID 24758Sodium hydrideHCID 1355277641-[(6-chloropyridin-3-yl)methyl]-N-nitroimidazolidin-2-imineHCID 178418361HCID 178418361, compound

Product 1

HCID 537042951-(2-Chloro-5-pyridylmethyl)-3-isopropyl-2-nitroiminoimidazolidine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

0.4 g of sodium hydride 60% in oil was added portionwise to a solution of 2.6 g of 1-(2-chloro-5-pyridylmethyl)-2-nitroiminoimidazolidine in 20 ml of dry dimethylformamide. The mixture was stirred at room temperature until the evolution of hydrogen ceased. A solution of 1.5 g of isopropyl bromide in 5 ml of dry dimethylformamide was added dropwise to the mixture at room temperature and stirred for 3 hours at room temperature after the addition. The reaction mixture was then poured into ice water, and the precipitated crystals filtered. This was recrystallized from ethanol to give 1-(2-chloro-5-pyridylmethyl)-3-isopropyl-2-nitroiminoimidazolidine. The yield was 1.5 g.

Workup

  1. additionafter the addition
  2. filtrationthe precipitated crystals filtered
  3. customThis was recrystallized from ethanol

Sources & evidence

ORD record
ord-9023536bacb342638ada8f1b07f380aa
Source dataset
uspto-grants-1995_06
Patent number
US05428032

Reaction notes

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