5-Chlorovaleryl chloride → Methyl 4-(5-chloro-pentanoyl-amino)-3-methoxy-benzoate

HRID 2222501Notes

Reaction equation

HRID 2222501 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[O:12][CH3:13].[Cl:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19](Cl)=[O:20]>C1COCC1>[Cl:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([NH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[O:12][CH3:13])=[O:20]

Participants

4

Reactant 2

HCID 740895-Chlorovaleryl chlorideHCID 602411Methyl 4-amino-3-methoxybenzoate

Product 1

HCID 67048137Methyl 4-(5-chloro-pentanoyl-amino)-3-methoxy-benzoate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to Example 6a from methyl 4-amino-3-methoxy-benzoate and 5-chloro-pentanoic acid chloride in THF with TEA.

Sources & evidence

ORD record
ord-7e7f19a420f44c469fbcb59bcf0f416c
Source dataset
uspto-grants-2008_05
Patent number
US07371743B2

Reaction notes

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