Hydrochloric Acid → HCID 17856383, compound

HRID 2222566Notes

Reaction equation

HRID 2222566 reaction equation
[ClH:1].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]=[CH:10][C:11]1([OH:16])[CH2:15][CH2:14][CH2:13][CH2:12]1.Cl>C(O)(C)C.C(OCC)C>[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]=[CH:10][C:11]1([OH:16])[CH2:15][CH2:14][CH2:13][CH2:12]1.[ClH:1].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]=[CH:10][C:11]1([OH:16])[CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 17856383HCID 17856383, compound

Product 2

HCID 17856382HCID 17856382, compoundHCID 17856383HCID 17856383, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 3776IsopropanolSolvent

Procedure

The 1-[(o-chlorophenyl)iminomethyl]cyclopentanol hydrochloride 3 was prepared by dissolving 20 g (0.089 mol) of the free base of compound 3 in 25 ml of isopropanol and to this solution was added 100 ml of hydrochloric acid (2N) in diethyl ether. The mixture was then stirred for 10 minutes, and the precipitate obtained was filtered, washed by diethyl ether and dried to give a white solid of the hydrochloride of compound 3 (23.14 g, 100%).

Workup

  1. customThe 1-[(o-chlorophenyl)iminomethyl]cyclopentanol hydrochloride 3 was prepared
  2. customthe precipitate obtained
  3. filtrationwas filtered
  4. washwashed by diethyl ether
  5. customdried

Sources & evidence

ORD record
ord-e92bd30600b54b28930d40218d3c1fb9
Source dataset
uspto-grants-2008_05
Patent number
US07371829B2

Reaction notes

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