Potassium Carbonate → HCID 58664769, compound

HRID 2222879Notes

Reaction equation

HRID 2222879 reaction equation
[C:1]([CH2:4][CH2:5][C@H:6]1[C:11](=[O:12])[NH:10][C:9]2[CH:13]=[C:14]([CH2:17][C@H:18]([NH:24][C:25]([O:27][CH2:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:26])[C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:15]=[CH:16][C:8]=2[O:7]1)(O)=[O:2].[NH2:33][C:34]1[NH:35][CH:36]=[CH:37][N:38]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C1C=CC2N(O)N=NC=2C=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:32][C:29]([CH3:30])([CH3:31])[CH2:28][O:27][C:25]([NH:24][C@@H:18]([CH2:17][C:14]1[CH:15]=[CH:16][C:8]2[O:7][C@@H:6]([CH2:5][CH2:4][C:1](=[O:2])[NH:33][C:34]3[NH:35][CH:36]=[CH:37][N:38]=3)[C:11](=[O:12])[NH:10][C:9]=2[CH:13]=1)[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[O:26]

Participants

7

Reactant 5

HCID 11430Potassium CarbonateHCID 757711-HydroxybenzotriazoleHCID 821402-AminoimidazoleHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 58664765HCID 58664765, compound

Product 1

HCID 58664769HCID 58664769, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3.2 g of 14 are reacted with 1.88 g of 2-aminoimidazole, 2.96 g of TBTU, 0.29 g of HOBt and 2.95 g of potassium carbonate in 40 ml of DMF analogously to the preparation of 5. Conventional work-up gives 15.

Sources & evidence

ORD record
ord-06277a23137843038eb5c2475cf6c477
Source dataset
uspto-grants-2008_05
Patent number
US07371854B2

Reaction notes

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