反应详情

To a solution of carnosine (5 g, 22.1 mmoles) in N,N-dimethylformamide (80 ml), triethylamine (4.62 ml, 33.1 mmoles) and 4-bromobutyrylchloride (chloride of 4-bromobutyric acid-83.85 ml, 33.1 mmoles) are added. The solution is left under stirring for 24 hours at room temperature, then it is diluted with ethyl acetate and the organic phase is washed with water. The organic phase is then anhydrified with sodium sulphate and evaporated at reduced pressure. The obtained crude product is purified by chromatography on silica gel eluting with ethyl acetate, obtaining the final product.

1. waitThe solution is left
2. washthe organic phase is washed with water
3. customevaporated at reduced pressure
4. customThe obtained crude product
5. customis purified by chromatography on silica gel eluting with ethyl acetate