Hydrogen Bromide → HCID 6918146, compound

HRID 2226323Notes

Reaction equation

HRID 2226323 reaction equation
FC(F)(F)C(O)=O.[CH3:8][O:9][C:10]([CH2:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH:21]([NH:23][CH2:24][CH:25]([C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([Cl:33])[CH:28]=2)[OH:26])[CH3:22])=[CH:16][CH:15]=1)=[O:11].[OH-].[NH4+].[BrH:36].Cl>C(O)C>[BrH:36].[CH3:8][O:9][C:10]([CH2:12][O:13][C:14]1[CH:15]=[CH:16][C:17]([CH2:20][CH:21]([NH:23][CH2:24][CH:25]([C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([Cl:33])[CH:28]=2)[OH:26])[CH3:22])=[CH:18][CH:19]=1)=[O:11]

Participants

6

Reactant 4

HCID 260Hydrogen BromideHCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 18967265HCID 18967265, compound

Product 1

HCID 6918146HCID 6918146, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

By neutralization of the product obtained in Example 10 with ammonium hydroxide, as described in Example 6, and salification with a solution of hydrogen bromide (instead of hydrogen chloride) in ethanol, the N-[2-(4-methoxycarbonylmethoxyphenyl)-1-methylethyl]-2-(3-chlorophenyl)-2-hydroxyethanamine hydrobromide is obtained.

Sources & evidence

ORD record
ord-88ee8d592d7f4c21b3c24271401e334f
Source dataset
uspto-grants-1994_09
Patent number
US05347037

Reaction notes

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