Methylparaben → HCID 18963625, compound

HRID 2226801Notes

Reaction equation

HRID 2226801 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH:8]=[CH2:9].[OH:10][C:11]1[CH:20]=[CH:19][C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:13][CH:12]=1.C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[CH2:2]([O:10][C:11]1[CH:12]=[CH:13][C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:19][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH:8]=[CH2:9]

Participants

5

Reactant 3

HCID 7456MethylparabenHCID 11430Potassium CarbonateHCID 759078-Bromooct-1-ene

Product 1

HCID 18963625HCID 18963625, compoundYield 68.6%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

5.2 g of 8-bromooctene, 5.0 g of methyl 4-hydroxybenzoate and 14 g of potassium carbonate were added to 70 ml of 2-butanone, and the mixture was refluxed for 7 hours in an atmosphere of argon. After the solid matters formed therein were filtered off, the solvent was distilled off under reduced pressure. The residue was purified by a silica gel column chromatography, to obtain 4.9 g of compound (8) (Yield: 68%)

Workup

  1. temperaturethe mixture was refluxed for 7 hours in an atmosphere of argon
  2. customAfter the solid matters formed
  3. filtrationtherein were filtered off
  4. distillationthe solvent was distilled off under reduced pressure
  5. customThe residue was purified by a silica gel column chromatography

Sources & evidence

ORD record
ord-37efddc110ef4a179aaa523eeb712815
Source dataset
uspto-grants-1994_09
Patent number
US05350538

Reaction notes

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