Benzyl Bromide → 2-(1-Benzylpiperidin-2-yl)ethan-1-ol

HRID 2227437Notes

Reaction equation

HRID 2227437 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][CH2:8][OH:9].[CH2:10](Br)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH2:10]([N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][CH2:8][OH:9])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

5

Reactant 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 151442-Piperidin-2-ylethanol

Product 1

HCID 102425512-(1-Benzylpiperidin-2-yl)ethan-1-olYield 100%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

2-Piperidineethanol (25.8 g, 0.2 mol), benzyl bromide (26.2 ml) and potassium carbonate (55.3 g) in acetonitrile (250 ml), as described above, gave 1-benzyl-2-piperidineethanol (43.8 g, 100%).

Sources & evidence

ORD record
ord-0799a95b340b4e9f9dd17761909f0657
Source dataset
uspto-grants-2002_07
Patent number
US06413987B1

Reaction notes

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