Methyl isothiocyanate → HCID 9937045, compound

HRID 2227569Notes

Reaction equation

[C:1]([C:5]1[CH:6]=[CH:7][C:8]([O:31][CH3:32])=[C:9]([CH:30]=1)[C:10]([NH:12][CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][C:18]([O:25][CH2:26][CH2:27][O:28][CH3:29])=[C:19]([S:21]([NH2:24])(=[O:23])=[O:22])[CH:20]=1)=[O:11])([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[H-].[Na+].[CH3:41][N:42]=[C:43]=[S:44]>>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([O:31][CH3:32])=[C:9]([CH:30]=1)[C:10]([NH:12][CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][C:18]([O:25][CH2:26][CH2:27][O:28][CH3:29])=[C:19]([S:21]([NH:24][C:43]([NH:42][CH3:41])=[S:44])(=[O:23])=[O:22])[CH:20]=1)=[O:11])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 4

HCID 11167Methyl isothiocyanate

HCID 11430Potassium Carbonate

HCID 24758Sodium hydride

HCID 18474327HCID 18474327, compound

Product 1

HCID 9937045HCID 9937045, compound

Procedure

The preparation was carried out analogously to Example 1 using 5-[2-(5-tert-butyl-2-methoxybenzamido)ethyl]-2-(2-methoxyethoxy)benzenesulfonamide. Instead of potassium carbonate, sodium hydride was used as base in the reaction with methyl isothiocyanate analogously to Example 5. The product had a melting point of 61° C.

Sources & evidence

ORD record: ord-9d51e3325afc4582abd28e68f24adebd
Source dataset: uspto-grants-2002_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06414030B1

Reaction notes

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