反应详情

温度

40 °C

A mixture of 4-(4-chloro-2-fluoroanilino)-7-hydroxy-6-methoxyquinazoline (957 mg, 3 mmol), (prepared as described for the starting material in Example 2), 1-bromo-3-chloropropane (2.36 g, 15 mmol) and potassium carbonate (2.1 g, 15 mmol) in DMF (20 ml) was heated at 40° C. for 1.5 hours. The mixture was allowed to cool, was diluted with water and extracted with ethyl acetate (3×50 ml). The organic extracts were combined, washed with water and brine, dried (MgSO4) and the volatiles were removed by evaporation. The residue was triturated with hexanelethyl acetate, collected by filtration and dried under vacuum to give 4-(4-chloro-2-fluoroaniiino)-7-(3-chloropropoxy)-6-methoxyquinazoline (650 mg, 55%).

1. custom(prepared
2. temperatureto cool
3. extractionextracted with ethyl acetate (3×50 ml)
4. washwashed with water and brine
5. dry with materialdried (MgSO4)
6. customthe volatiles were removed by evaporation
7. customThe residue was triturated with hexanelethyl acetate
8. filtrationcollected by filtration
9. customdried under vacuum