Imidazole → 2-(Imidazol-1-yl)propiophenone

HRID 2227987Notes

Reaction equation

HRID 2227987 reaction equation
Br[CH:2]([CH3:11])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].[NH:12]1[CH:16]=[CH:15][N:14]=[CH:13]1.C(C(CC)(CC)CN)C.C(OCC)(=O)C>O>[N:12]1([CH:2]([CH3:11])[C:3]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)=[O:4])[CH:16]=[CH:15][N:14]=[CH:13]1

Participants

6

Reactant 4

HCID 795ImidazoleHCID 8857Ethyl AcetateHCID 164522-BromopropiophenoneHCID 15841159HCID 15841159, compound

Product 1

HCID 132826052-(Imidazol-1-yl)propiophenoneYield 65%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2-bromopropiophenone (21.3 g, 0.1M), imidazole (20.4 g, 0.3M), triethylethylamine (30.3 g, 0.3M) and ethyl acetate (300 ml) was refluxed overnight, cooled to room temperature and treated with water. The organic phase was separated, dried over MgSO4 and evaporated to give 2-(imidazol-1-yl)propiophenone as a viscous oil (12.95 g,

Workup

  1. temperaturewas refluxed overnight
  2. customThe organic phase was separated
  3. dry with materialdried over MgSO4
  4. customevaporated

Sources & evidence

ORD record
ord-b59249805d4144ab9bc83d934507deee
Source dataset
uspto-grants-2002_07
Patent number
US06414145B1

Reaction notes

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