反应详情

温度

20 °C

10.00 kg (43.6 mol) of methyl 3-(bromomethyl)benzoate and 5.21 kg (43.74 mol) of 4-hydroxybenzonitrile are dissolved in 100 liters of acetone and stirred with 8.4 kg (60.7 mol) of potassium carbonate in the presence of 0.1 kg of sodium iodide for about 4 h under reflux conditions. Then 35 liters of acetone are distilled off and 100 liters of water are added at reflux conditions. The reaction mixture is cooled to 20° C. and the crystallisation is completed by the addition of another 30 liters of water. The crystals formed are separated off, washed with 50 liters of water and dried in vacuo.

1. distillationThen 35 liters of acetone are distilled off
2. addition100 liters of water are added
3. temperatureat reflux conditions
4. customthe crystallisation
5. additionis completed by the addition of another 30 liters of water
6. customThe crystals formed
7. customare separated off
8. washwashed with 50 liters of water
9. customdried in vacuo