1H-1,2,4-Triazole → HCID 12973084, compound

HRID 2229246Notes

Reaction equation

HRID 2229246 reaction equation
Cl[CH2:2]/[CH:3]=[CH:4]/[C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=1.[NH:15]1[CH:19]=[N:18][CH:17]=[N:16]1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.C(OCC)(=O)C>[CH:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH:13]=[CH:14][C:5]=1/[CH:4]=[CH:3]/[CH2:2][N:15]1[CH:19]=[N:18][CH:17]=[N:16]1

Participants

6

Reactant 3

HCID 92571H-1,2,4-TriazoleHCID 11430Potassium CarbonateHCID 12965767HCID 12965767, compound

Product 1

HCID 12973084HCID 12973084, compoundYield 10.3%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of (E)-1-chloro-3-(2-naphthyl)-2-propene (0.5 g), 1H-1,2,4-triazole (0.5 g) and K2CO3(1.0 g) in DMF (20 ml) was stirred for 14 hours. The mixture was diluted with ethyl acetate and insolubles were filtered off. The filtrate was concentrated in vacuo and the residue was chromatographed on silica gel, eluting with ethyl acetate to give the titled compound (0.06 g) as colorless powder.

Workup

  1. filtrationwere filtered off
  2. concentrationThe filtrate was concentrated in vacuo
  3. customthe residue was chromatographed on silica gel
  4. washeluting with ethyl acetate

Sources & evidence

ORD record
ord-7549bfbb2c5c47f38d9cb04211d1469e
Source dataset
uspto-grants-2002_07
Patent number
US06420375B1

Reaction notes

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