反应详情

Diethyl azodicarboxylate (DEAD) (160 μL, 1.01 mmol) was added drop-wise to a solution of 2-chloro-5,11-dihydro-11-ethyl-8-(2-hydroxyethyl)-5-methyl-6H-dipyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one (225 mg, 0.68 mmol), 5-hydroxyquinoline (147 mg, 1.01 mmol) and Ph3P (266 mg, 1.01 mmol) in THF (3.4 mL) at room temperature. The mixture was stirred at room temperature for 3 h then was concentrated under reduced pressure. The residue was partially purified by flash chromatography (EtOAc:MeOH; 95:5). The fractions containing the 5-quinolinyloxy derivative were concentrated, dissolved in CH2Cl2 (2 mL) and THF (5 mL) and treated with mCPBA (80%, 248 mg, 1.15 mmol) at room temperature. The solution was stirred at room temperature for 2.5 h, then was concentrated under reduced pressure. The residue was dissolved in EtOAc (50 mL), washed successively with aqueous 10% Na2S2O3 (3×10 mL), aqueous saturated NaHCO3 (3×10 mL) and brine (10 mL), then was dried (MgSO4), filtered and concentrated under reduced pressure. The residue was purified by flash chromatography (EtOAc:MeOH, 95:5 to CH2Cl2:MeOH, 9:1) to give the title compound (113 mg, 35% yield for 2 steps) as a white solid: MS (ESI) m/z 476/478 (MH)+.

1. concentrationthen was concentrated under reduced pressure
2. customThe residue was partially purified by flash chromatography (EtOAc:MeOH; 95:5)
3. additionThe fractions containing the 5-quinolinyloxy derivative
4. concentrationwere concentrated
5. dissolutiondissolved in CH2Cl2 (2 mL)
6. stirringThe solution was stirred at room temperature for 2.5 h
7. concentrationwas concentrated under reduced pressure
8. dissolutionThe residue was dissolved in EtOAc (50 mL)
9. washwashed successively with aqueous 10% Na2S2O3 (3×10 mL), aqueous saturated NaHCO3 (3×10 mL) and brine (10 mL)
10. dry with materialwas dried (MgSO4)
11. filtrationfiltered
12. concentrationconcentrated under reduced pressure
13. customThe residue was purified by flash chromatography (EtOAc:MeOH, 95:5 to CH2Cl2:MeOH, 9:1)