Sodium Bicarbonate → HCID 18467684, compound

HRID 2229428Notes

Reaction equation

HRID 2229428 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][CH2:11][C:12]1[CH:17]=[C:16]([O:18][CH3:19])[C:15]([O:20][CH3:21])=[C:14]([O:22][CH3:23])[CH:13]=1)([O-])=O.C(=O)(O)[O-].[Na+]>C(OCC)(=O)C>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][CH2:11][C:12]1[CH:13]=[C:14]([O:22][CH3:23])[C:15]([O:20][CH3:21])=[C:16]([O:18][CH3:19])[CH:17]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 8461456HCID 8461456, compound

Product 1

HCID 18467684HCID 18467684, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

[(2-Nitrophenyl)]-3,4,5-trimethoxybenzylamine (15.01 mmol, 5.0 g) in ethyl acetate (150 ml) is charged with SnCl22H2O (94.2 mmol, 7.84 ml), and is refluxed for four (4) hours. The mixture is poured into ice water (100 g), sodium bicarbonate is added to achieve pH 7. and the reaction mixture is extracted with ethyl acetate (3×50 ml). The organic layers are dried with MgSO4, are filtered and evaporated (45%)

Workup

  1. additionis added
  2. extractionand the reaction mixture is extracted with ethyl acetate (3×50 ml)
  3. dry with materialThe organic layers are dried with MgSO4
  4. filtrationare filtered
  5. customevaporated (45%)

Sources & evidence

ORD record
ord-dd15fb566d0047ab9e701a86dcf14759
Source dataset
uspto-grants-2002_07
Patent number
US06420410B1

Reaction notes

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