Chloromethyl methyl sulfide → HCID 21286304, compound

HRID 2231252Notes

Reaction equation

HRID 2231252 reaction equation
[OH:1][CH2:2][C:3]1[NH:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[H-].[Na+].[CH3:14][S:15][CH2:16]Cl>CN(C)C=O>[CH3:14][S:15][CH2:16][N:7]1[C:6]2[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=2[N:4]=[C:3]1[CH2:2][OH:1]

Participants

5

Reactant 3

HCID 16916Chloromethyl methyl sulfideHCID 24758Sodium hydrideHCID 785692-(Hydroxymethyl)-1H-benzimidazole

Product 1

HCID 21286304HCID 21286304, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using the procedure of Preparation C1, 14.8 g of 2-hydroxymethylbenzimidazole, 4.8 g of 50% sodium hydride in oil and 8.36 ml of chloromethyl methyl sulfide in 50 ml of dimethylformamide gave 8.3 g of product.

Sources & evidence

ORD record
ord-4a332dc46a4f41f7855d3e963d5d670b
Source dataset
uspto-grants-1988_11
Patent number
US04782050

Reaction notes

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