反应详情

8.15 g of N-hydroxyphthalimide was dissolved in 300 ml of N,N-dimethylformamide, 6.91 g of potassium carbonate and 200 mg of dicyclohexyl-18-crown-6 were added, and stirred at room temperature for 2 hours. Thereafter, 9.82 g of 4-chloromethyl-2-tritylaminothiazol was added thereto, and stirred and reacted at room temperature for 8 hours. The reaction mixture was concentrated under reduced pressure, and, after adding 500 ml of ethyl acetate, washed with 300 ml of water 4 times. The ethyl acetate layer was dried on anhydrous magnesium sulfate, and concentrated to dryness to obtain 12.5 g of (2-tritylaminothiazol-4-yl)methoxyphthalimide.

1. stirringstirred
2. customreacted at room temperature for 8 hours
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. additionafter adding 500 ml of ethyl acetate
5. washwashed with 300 ml of water 4 times
6. dry with materialThe ethyl acetate layer was dried on anhydrous magnesium sulfate
7. concentrationconcentrated to dryness