Hydrazine hydrate (1:1) → HCID 67713563, compound

HRID 223207Notes

Reaction equation

HRID 223207 reaction equation
[CH3:1][N:2]1[C:8](=[O:9])[C:7]2[CH:10]=[CH:11][CH:12]=[CH:13][C:6]=2[N:5]2[CH:14]=[N:15][C:16]([C:17]([O:19]CC)=O)=[C:4]2[CH2:3]1.O.[NH2:23][NH2:24]>C(O)C>[CH3:1][N:2]1[C:8](=[O:9])[C:7]2[CH:10]=[CH:11][CH:12]=[CH:13][C:6]=2[N:5]2[CH:14]=[N:15][C:16]([C:17]([NH:23][NH2:24])=[O:19])=[C:4]2[CH2:3]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 127597Ro 14-7437

Product 1

HCID 67713563HCID 67713563, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

50 g (187.3 mmol) of ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate in 400 ml of ethanol are heated to boiling under reflux for 2 hours together with 150 ml of hydrazine hydrate. The precipitated material is filtered off under suction and dried. There is obtained 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid hydrazide of melting point 312°-313°.

Workup

  1. filtrationThe precipitated material is filtered off under suction
  2. customdried

Sources & evidence

ORD record
ord-3543cac12be5414f9f3ebfb1ff187811
Source dataset
uspto-grants-1982_10
Patent number
US04352818

Reaction notes

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