4-Pyridinecarboxaldehyde → HCID 137192606, compound

HRID 2232092Notes

Reaction equation

HRID 2232092 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]=O)=[CH:3][CH:2]=1.[ClH:9].[NH2:10][OH:11]>CO>[ClH:9].[N:1]1[CH:6]=[CH:5][C:4]([CH:7]=[N:10][OH:11])=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 133894-PyridinecarboxaldehydeHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 137192606HCID 137192606, compoundYield 73.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4-pyridine carboxaldehyde (25.0 g, 233 mmol) in 100 ml of methanol was treated with hydroxylamine hydrochloride (17.84 g, 250 mmol) and stirred 15 minutes at room temperature. The resulting white solid was collected by filtration and dried in vacuo to provide 27.0 g of 4-pyridine carboxaldehyde oxime, hydrochloride, mp 246°-247° C.

Workup

  1. filtrationThe resulting white solid was collected by filtration
  2. customdried in vacuo

Sources & evidence

ORD record
ord-bd302f57bbee401283b20fd4682b4074
Source dataset
uspto-grants-1988_11
Patent number
US04786648

Reaction notes

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