反应详情

In a manner similar to Step D of Example 1, the reaction of 1.3 gram (0.013 mole) of phenylacetylene, 50 ml of triethylamine, 3.2 grams (0.011 mole) of 5-iodo-2-(thien-2-yl)thiazole, 0.080 gram (1.1×10-4 mole) of dichlorobis(triphenylphosphine)palladium (II), and 0.022 gram (1.1×10-4 mole) of copper(I) iodide produced 2.1 grams of 1-phenyl-2-[2-(thien-2-yl)thiazol-5-yl]ethyne as a solid, m.p. 94°-96° C., Compound 22 of Table 1.