2-Amino-3-benzyloxypyridine → 8-(Benzyloxy)imidazo[1,2-a]pyridine

HRID 2232434Notes

Reaction equation

HRID 2232434 reaction equation
[NH2:1][C:2]1[C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.Br[CH2:17][CH:18]=O.C(=O)([O-])O.[Na+]>O1CCCC1>[CH2:9]([O:8][C:7]1[C:2]2[N:3]([CH:17]=[CH:18][N:1]=2)[CH:4]=[CH:5][CH:6]=1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

5

Reactant 3

HCID 903342-Amino-3-benzyloxypyridineHCID 105131Acetaldehyde, bromo-HCID 516892Sodium Bicarbonate

Product 1

HCID 134329748-(Benzyloxy)imidazo[1,2-a]pyridine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-Amino-3-benzyloxypyridine is reacted with bromoacetaldehye in aqueous tetrahydrofuran in the presence of sodium hydrogen carbonate, whereby the above-identified compound is obtained.

Workup

  1. customis obtained

Sources & evidence

ORD record
ord-3ea6532eee3f4137af696f061fdf8ff4
Source dataset
uspto-grants-1988_11
Patent number
US04788185

Reaction notes

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