Methyl Acrylate → beta-Hydroxy-alpha-methylenebenzeneheptanoic acid methyl ester

HRID 2232654Notes

Reaction equation

HRID 2232654 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH:11]=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:13]([O:17][CH3:18])(=[O:16])[CH:14]=[CH2:15].N12CCN(CC1)CC2>>[CH3:18][O:17][C:13](=[O:16])[C:14](=[CH2:15])[CH:11]([OH:12])[CH2:10][CH2:9][CH2:8][CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 7294Methyl AcrylateHCID 9237DabcoHCID 561886Benzenepentanal

Product 1

HCID 14348901beta-Hydroxy-alpha-methylenebenzeneheptanoic acid methyl ester

Procedure

A mixture of 8.4 g (52 mmol) of 5-phenylpentanal, 8.95 g (104 mmol) of methyl acrylate and 200 mg of 1,4-diazabicyclo[2.2.2]octane is allowed to stand at room temperature for 120 hours.

Sources & evidence

ORD record
ord-28e14a4b6f5943cabbed693ec45faa3d
Source dataset
uspto-grants-1988_11
Patent number
US04788306

Reaction notes

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