Hydrochloric Acid → HCID 59296096, compound

HRID 2233385Notes

Reaction equation

HRID 2233385 reaction equation
Cl[S:2]([C:5]1[CH:14]=[C:13]2[C:8]([C:9]([C:16]([OH:18])=[O:17])=[CH:10][NH:11][C:12]2=[O:15])=[CH:7][CH:6]=1)(=[O:4])=[O:3].C(N(C(C)C)CC)(C)C.Cl.[CH3:29][C:30]1([OH:34])[CH2:33][NH:32][CH2:31]1.Cl>O1CCCC1>[OH:34][C:30]1([CH3:29])[CH2:33][N:32]([S:2]([C:5]2[CH:14]=[C:13]3[C:8]([C:9]([C:16]([OH:18])=[O:17])=[CH:10][NH:11][C:12]3=[O:15])=[CH:7][CH:6]=2)(=[O:4])=[O:3])[CH2:31]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 81531DiisopropylethylamineHCID 115427813-methylazetidin-3-ol HydrochlorideHCID 59295966HCID 59295966, compound

Product 1

HCID 59296096HCID 59296096, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

7-(Chlorosulfonyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid (1 g), diisopropylethylamine (3 ml) and 3-methylazetidin-3-ol hydrochloride (0.8 g) in tetrahydrofuran (8 ml) were heated at 55° C. for 3 days. The mixture was acidified with hydrochloric acid and then filtered to yield 7-[(3-hydroxy-3-methylazetidin-1-yl)sulfonyl]-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid as a pale pink solid.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-7898d35bb06f47f288fb42d545f02b5c
Source dataset
uspto-grants-2010_05
Patent number
US07709500B2

Reaction notes

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