Chlorzoxazone → HCID 131728101, compound

HRID 2233530Notes

Reaction equation

HRID 2233530 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8](=[O:10])[NH:7][C:6]=2[CH:11]=1.N([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=C=O.C(N(C(C)C)C(C)C)C>C1COCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8](=[O:10])[NH:7][C:6]=2[CH:11]=1.[CH3:20][CH2:19][CH:18]([C:8]([NH2:7])=[O:9])[CH2:17][CH2:16][CH3:15]

Participants

5

Reactant 3

HCID 2733ChlorzoxazoneHCID 75659Hexyl isocyanateHCID 81531Diisopropylethylamine

Product 1

HCID 131728101HCID 131728101, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

100 mg (0.59 mmol) of 5-chloro-3H-benzooxazol-2-one were reacted in analogy to Example 1 with 112.6 mg (0.885 mmol) of 1-isocyanatohexane in the presence of ethyldiisopropylamine in THF at 70° C. Yield: 125 mg (71%), M+H+: 297.1.

Sources & evidence

ORD record
ord-e405f35c22774b2981de06c8e7155165
Source dataset
uspto-grants-2010_05
Patent number
US07709513B2

Reaction notes

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