反应详情

温度

50 °C

A mixture of the product from step (i) (0.45 g), potassium carbonate (0.415 g) and methyl bromoacetate (0.21 ml) in DMF (3 ml) was stirred at 50° C. for 3 h. The reaction was partitioned between ethylacetate/water. The organics were washed with water, dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 5-15% ethylacetate/iso-hexane. Yield 0.33 g

1. customThe reaction was partitioned between ethylacetate/water
2. washThe organics were washed with water
3. customdried
4. customevaporated under reduced pressure
5. customThe residue was purified by chromatography on silica eluting with 5-15% ethylacetate/iso-hexane