反应详情

4-Bromo-5-methyl-1H-pyrrole-2-carboxylic acid (Intermediate 18, 2.16 g, 10.59 mmol) was dissolved an THF (10 ml). Pentafluorophenol and EDC (2.03 g, 10.59 mmol) were added and the mixture was stirred at room temperature for 6 h. The solvent was removed under vacuum and EtOAc (50 ml) was added. The organic phase was washed with water, 10% Na2CO3 (2×25 ml), water (50 ml) and brine (50 ml), dried over Na2SO4 and concentrated in vacuo to give the title compound as an off white solid (2.23 g).

1. customThe solvent was removed under vacuum and EtOAc (50 ml)
2. additionwas added
3. washThe organic phase was washed with water, 10% Na2CO3 (2×25 ml), water (50 ml) and brine (50 ml)
4. dry with materialdried over Na2SO4
5. concentrationconcentrated in vacuo