Phenacyl bromide → HCID 22462654, compound

HRID 2234154Notes

Reaction equation

HRID 2234154 reaction equation
[CH2:1]([N:3]([CH2:6][CH3:7])[CH2:4][CH3:5])[CH3:2].[CH2:8]([Br:17])[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10]>CO>[Br-:17].[CH2:1]([N+:3]([CH2:6][CH3:7])([CH2:4][CH3:5])[CH2:8][C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10])[CH3:2]

Participants

4

Reactant 2

HCID 6259Phenacyl bromideHCID 8471Triethylamine

Product 1

HCID 22462654HCID 22462654, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A reaction vessel was charged with 10.1 g of triethylamine, 19.9 g of phenacylbromide and 200 g of methanol, and they were stirred at room temperature for 6 hours. By evaporating methanol from this solution, 29.9 g of a white crystalline matter were obtained. This was washed with diethyl ether, then dried under reduced pressure, to obtain 24.9 g of an intermediate triethylphenacyl ammonium bromide (yield: 83%).

Workup

  1. customBy evaporating methanol from this solution, 29.9 g of a white crystalline matter
  2. customwere obtained
  3. washThis was washed with diethyl ether
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-e189102e59c442e5bef0f7c0bec08536
Source dataset
uspto-grants-2010_05
Patent number
US07709598B2

Reaction notes

Loading…