Triethylamine → HCID 54339371, compound

HRID 2234424Notes

Reaction equation

HRID 2234424 reaction equation
[NH2:1][C:2]1[C:3]([Cl:9])=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.C(N(CC)CC)C.Cl[CH2:18][CH2:19][C:20](Cl)=[O:21]>C1COCC1>[Cl:8][C:5]1[N:4]=[C:3]([Cl:9])[C:2]([NH:1][C:20](=[O:21])[CH:19]=[CH2:18])=[CH:7][N:6]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 693643-Chloropropionyl chlorideHCID 2577975-Amino-2,4-dichloropyrimidine

Product 1

HCID 54339371HCID 54339371, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 5-Amino-2,4-dichloropyrimidine (Chempacific; 100 mg, 0.610 mmol) in THF (2 mL) was added triethylamine (170 μL, 1.22 mmol) followed by 3-Chloropropionyl Chloride (Aldrich; 64 mL, 0.671 mmol) The reaction was stirred at room temperature for 18 hrs.

Sources & evidence

ORD record
ord-6aa11810028e4c4294750143955e2a36
Source dataset
uspto-grants-2010_05
Patent number
US07709471B2

Reaction notes

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