huagongshe.com
HRID2235340

反应详情

EQUATION

反应方程式

HRID 2235340 的结构方程式

REACTANTS

反应物

4
结构：CC#N
HCID6342

Acetonitrile

C2H3N

结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：CCCCCI
HCID12335

Pentane, 1-iodo-

C5H11I

结构：CC(=O)Nc1cc2c(cc1[N+](=O)[O-])NC(=O)C2(C)C
HCID23092658

N-(3,3-Dimethyl-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl)acetamide

C12H13N3O4

PRODUCTS

生成物

1
结构：CCCCCN1C(=O)C(C)(C)c2cc(N)c([N+](=O)[O-])cc21
HCID17802744

未命名化合物

收率 73.6%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：Cl
溶剂HCID313

Hydrochloric Acid

ClH

结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

Analogously to general procedure (I) N-(3,3-dimethyl-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl)-acetamide (50 g) is alkylated using pentyliodide (76.8 g; 0.38 mol) and K2CO3 (53.6 g; 0.38 mol) at 60° C. for 24 h. After aqueous work-up the crude material is de-acetylated under reflux in 2-propanol (500 ml) and hydrochloric acid (6 N; 300 ml). After aqueous work-up pure 5-amino-3,3-dimethyl-6-nitro-1-pentyl-1,3-dihydro-indol-2-one (40.7 g) is obtained by re-crystallization from MeCN.

WORKUP

后处理

  1. customat 60° C.
  2. customfor 24 h