Triphenylphosphine → tert-Butyl 3-((4-((S)-3-((S)-4-benzyl-2-oxooxazolidin-3-yl)-1-(isoxazol-3-yl)-3-oxopropyl)phenoxy)methyl)phenylcarbamate

HRID 2235599Notes

Reaction equation

HRID 2235599 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH:6]=[CH:7][CH:8]=1.[CH2:17]([C@H:24]1[CH2:28][O:27][C:26](=[O:29])[N:25]1[C:30](=[O:45])[CH2:31][C@@H:32]([C:38]1[CH:43]=[CH:42][C:41](O)=[CH:40][CH:39]=1)[C:33]1[CH:37]=[CH:36][O:35][N:34]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.CC(OC(/N=N/C(OC(C)C)=O)=O)C.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C1COCC1>[CH2:17]([C@H:24]1[CH2:28][O:27][C:26](=[O:29])[N:25]1[C:30](=[O:45])[CH2:31][C@@H:32]([C:38]1[CH:39]=[CH:40][C:41]([O:1][CH2:2][C:3]2[CH:4]=[C:5]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:13])([CH3:15])[CH3:14])[CH:6]=[CH:7][CH:8]=2)=[CH:42][CH:43]=1)[C:33]1[CH:37]=[CH:36][O:35][N:34]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

6

Reactant 4

HCID 11776TriphenylphosphineHCID 5363146Diisopropyl azodicarboxylateHCID 14523557tert-Butyl (3-(hydroxymethyl)phenyl)carbamateHCID 57801829(S)-4-Benzyl-3-((S)-3-(4-hydroxyphenyl)-3-(isoxazol-3-yl)propanoyl)oxazolidin-2-one

Product 1

HCID 59300702tert-Butyl 3-((4-((S)-3-((S)-4-benzyl-2-oxooxazolidin-3-yl)-1-(isoxazol-3-yl)-3-oxopropyl)phenoxy)methyl)phenylcarbamateYield 96.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of alcohol 27.1 (179 mg, 0.765 mmol) in THF (7 mL), was added phenol 7.5 (300 mg, 0.765 mmol), DIAD (0.155 mL, 0.803 mmol), and triphenylphosphine (211 mg, 0.803 mmol). The solution was stirred for 16 hours and then concentrated to a reduced volume. The residue was purified by medium pressure chromatography (silica gel, 0 to 50% EtOAc:hexanes) to give 27.2 (440 mg). MS ESI (pos.) m/e 598.2 (M+H). 1H NMR (400 MHz, CDCl3) δ ppm 8.20 (1H, d, J=1.6 Hz), 7.38 (1H, s), 7.08-7.29 (8H, m), 7.00 (1H, d), 6.82 (2H, d, J=8.6 Hz), 6.54 (1H, s), 6.33 (1H, br. s.), 6.05 (1H, d, J=1.6 Hz), 4.92 (2H, s), 4.85-4.90 (1H, m), 4.66 (1H, dd, J=1.6 Hz), 4.49-4.58 (1H, m), 4.01-4.04 (1H, m), 3.93 (1H, dd, J=17.6, 8.2 Hz), 3.45 (1H, dd, J=17.6, 6.7 Hz), 3.11 (1H, dd, J=13.5, 3.3 Hz), 2.68 (1H, dd, J=13.3, 9.4 Hz), 1.43 (9H, s).

Workup

  1. concentrationconcentrated to a reduced volume
  2. customThe residue was purified by medium pressure chromatography (silica gel, 0 to 50% EtOAc:hexanes)

Sources & evidence

ORD record
ord-64417975e9c04c23b57f8ab8a21f3883
Source dataset
uspto-grants-2010_05
Patent number
US07714008B2

Reaction notes

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