Potassium Carbonate → (2-Methyl-imidazol-1-yl)-acetic acid methyl ester

HRID 2236092Notes

Reaction equation

HRID 2236092 reaction equation
[CH3:1][O:2][C:3](=[O:6])[CH2:4]Br.[CH3:7][C:8]1[NH:9][CH:10]=[CH:11][N:12]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:1][O:2][C:3](=[O:6])[CH2:4][N:9]1[CH:10]=[CH:11][N:12]=[C:8]1[CH3:7]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 127492-MethylimidazoleHCID 60984Methyl bromoacetate

Product 1

HCID 28940036(2-Methyl-imidazol-1-yl)-acetic acid methyl esterYield 47%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4 ml of bromo acetic acid methyl ester is dissolved in 30 ml DMF and 5.2 g of 2-methylimidazole and 11.2 g potassium carbonate are added. The reaction mixture is stirred at room temperature for several hours and then subjected to aqueous work up. After removal of the solvent the pure product is obtained by flash chromatography in 47 to 78% yield.

Workup

  1. customAfter removal of the solvent the pure product
  2. customis obtained by flash chromatography in 47 to 78% yield

Sources & evidence

ORD record
ord-a0efcce04caf4190b157c3e4815db5b7
Source dataset
uspto-grants-2010_05
Patent number
US07714135B2

Reaction notes

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