Piperidine → HCID 25264202, compound

HRID 2236125Notes

Reaction equation

HRID 2236125 reaction equation
[CH3:1][N:2]([CH3:15])[C:3]1[N:7]=[C:6]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=[C:5]2[C:4]=1[CH:13]=[O:14].[NH:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18][C:17]1=[O:25].N1CC[CH2:29][CH2:28][CH2:27]1>CC(O)C>[CH3:1][N:2]([CH3:15])[C:3]1[N:7]=[C:6]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=[C:5]2[C:4]=1/[CH:13]=[C:18]1/[C:17](=[O:25])[NH:16][C:24]2[C:19]/1=[CH:20][CH:21]=[CH:22][CH:23]=2.[CH3:27][CH:28]([OH:14])[CH3:29]

Participants

5

Reactant 3

HCID 8082PiperidineHCID 321710OxindoleHCID 86620348HCID 86620348, compound

Product 1

HCID 25264202HCID 25264202, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

20 mg (4Z,6Z,8E)-2-(dimethylamino)cyclohepta[b]pyrrole-3-carbaldehyde, 25 mg oxindole, and 0.1 mg piperidine were added in IPA with reflux for 20 hours. After cooling, red crystals were precipitated. After filtration and washing by IPA, Compound 035 was obtained (55%).

Workup

  1. temperaturewith reflux for 20 hours
  2. temperatureAfter cooling
  3. customred crystals were precipitated
  4. filtrationAfter filtration
  5. washwashing by IPA

Sources & evidence

ORD record
ord-aebbc2d55674442bafda6e0a9a6aa9c3
Source dataset
uspto-grants-2010_05
Patent number
US07714146B2

Reaction notes

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