Potassium Carbonate → HCID 28387482, compound

HRID 2236205Notes

Reaction equation

HRID 2236205 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[CH3:11][NH:12][CH2:13][CH2:14][C:15]#[N:16].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C.CCOC(C)=O>[CH3:11][N:12]([C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1)[CH2:13][CH2:14][C:15]#[N:16]

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 69656Propanenitrile, 3-(methylamino)-HCID 783082-Chloro-5-nitropyridine

Product 1

HCID 28387482HCID 28387482, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

2-Chloro-5-nitropyridine (158 mg, 1 mmol), 3-methylamino-propionitrile (84 mg, 1 mmol), and finely ground potassium carbonate (414 mg, 3 mmol) were heated to 80° C. in 10 mL anhydrous DMF for 3.5 hrs. The mixture was diluted with EtOAc, extracted with H2O and dried over MgSO4. The EtOAc layer was filtered, evaporated to dryness. ES-MS calcd for C9H10N4O2 (m/e) 206.21, obsd 207.1 (M+H).

Workup

  1. extractionextracted with H2O
  2. dry with materialdried over MgSO4
  3. filtrationThe EtOAc layer was filtered
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-d8e431630f774a0a90ed0f54ab2fa9e5
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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