反应详情

A mixture of 1-(4-hydroxy-2-methyl-phenyl)-ethanone (15.0 g, 0.10 mole), sodium iodide (15.0 g, 0.10 mole), 4-(2-chloro-ethyl)-morpholine; hydrochloride (18.6 g, 0.10 mole), anhydrous powdered potassium carbonate (67.0 g, 0.50 mole) and 2-butanone (500 mL) is stirred and heated at a gentle reflux overnight. The mixture is cooled to room temperature, filtered, the solids washed with acetone. The combined filtrates were evaporated in-vacuo, the residue treated with water and extracted with ether. The ether layer is washed with 1N sodium hydroxide, water, brine, dried over anhydrous sodium sulfate, filtered and evaporated to give an oil, 19.2 g. (73%) used as is for the next step.

1. temperatureheated at
2. temperaturea gentle reflux overnight
3. filtrationfiltered
4. washthe solids washed with acetone
5. customThe combined filtrates were evaporated in-vacuo
6. additionthe residue treated with water
7. extractionextracted with ether
8. washThe ether layer is washed with 1N sodium hydroxide, water, brine
9. dry with materialdried over anhydrous sodium sulfate
10. filtrationfiltered
11. customevaporated
12. customto give an oil, 19.2 g