Triethylamine → HCID 178518266, compound

HRID 2236650Notes

Reaction equation

HRID 2236650 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])[C:5]2=[CH:14]OC.Cl.[NH2:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[OH:26].CCN(CC)CC>CN(C)C=O>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])/[C:5]/2=[CH:14]\[NH:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[OH:26]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 220584652-(Aminomethyl)phenol--hydrogen chloride (1/1)HCID 686927644-methoxymethylene-6-bromo-4H-isoquinoline-1,3-dione

Product 1

HCID 178518266HCID 178518266, compoundYield 30%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a mixture of 6-bromo-4-methoxymethylene-4H-isoquinoline-1,3-dione (194 mg, 0.69 mmol) and 2-aminomethyl-phenol hydrochloride salt (110 mg, 0.69 mmol) in N,N-dimethylformamide (DMF) (5 mL) is added Et3N (0.145 mL, 1.04 mmol). The precipitate is filtered to give 76 mg (30%) of the title compound as a beige solid. MS (ESI) m/z 371.0 (M−H)−1.

Workup

  1. filtrationThe precipitate is filtered

Sources & evidence

ORD record
ord-1dd1f45909744f29a7bd09100a06882a
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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