2-Amino-5-methylpyridine → N-cyclohexyl-6-methyl-2-(2-methyl-1H-imidazol-5-yl)imidazo[1,2-a]pyridin-3-amine

HRID 224185Notes

Reaction equation

HRID 224185 reaction equation
CC1=CC=C(N)N=C1.[C-]#[N+]C1CCCCC1.CC1=NC=C(N1)C=O>>CC1=NC=C(N1)C1=C(NC2CCCCC2)N2C=C(C)C=CC2=N1

Participants

6

Reactant 3

HCID 153482-Amino-5-methylpyridineHCID 79129Cyclohexyl isocyanideHCID 27958782-Methyl-1H-imidazole-4-carboxaldehyde

Product 1

HCID 174193255N-cyclohexyl-6-methyl-2-(2-methyl-1H-imidazol-5-yl)imidazo[1,2-a]pyridin-3-amineYield 23.52%

Reagents, catalysts & solvents 2

HCID 6422Trifluoroacetic acidCatalystHCID 3776IsopropanolSolvent2×

Conditions

Temperature
22 °C

Sources & evidence

ORD record
ord-015e79d343774884a8b49ae5d80ef5b1
Source dataset
Imidazopyridines dataset

Reaction notes

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