Hydrochloric Acid → Fexofenadine

HRID 2242091Notes

Reaction equation

HRID 2242091 reaction equation
[CH3:1][C:2]([C:35]([OH:37])=[O:36])([C:4]1[CH:5]=[CH:6][C:7]([CH:10]([OH:34])[CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([C:20]([OH:33])([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH2:16][CH2:15]2)=[CH:8][CH:9]=1)[CH3:3].Cl.Cl>CO.C(O)(C)C>[CH3:3][C:2]([C:35]([OH:37])=[O:36])([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([OH:34])[CH2:11][CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][CH:17]([C:20]([OH:33])([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH2:18][CH2:19]2)=[CH:6][CH:5]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 63002Fexofenadine Hydrochloride

Product 1

HCID 3348Fexofenadine

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3776IsopropanolSolvent

Procedure

In another aspect, the present invention provides a process for preparing crystalline fexofenadine hydrochloride Form XVI comprising the steps of combining a solution of HCl in a mixture of methanol and isopropyl alcohol, with fexofenadine base, to obtain a solution, evaporating the methanol and the isopropyl alcohol to obtain a residue, adding a mixture of methanol and heptane to the residue to precipitate crystalline fexofenadine hydrochloride and recovering the fexofenadine hydrochloride.

Workup

  1. customIn another aspect, the present invention provides a process

Sources & evidence

ORD record
ord-d6b009adde0849b0aea62c9ca3b8c411
Source dataset
uspto-grants-2010_03
Patent number
US07671071B2

Reaction notes

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