HRID2242091

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CC(C)(C(=O)O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1.Cl

HCID63002

Fexofenadine Hydrochloride

C32H40ClNO4

PRODUCTS

生成物

结构：CC(C)(C(=O)O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1

HCID3348

Fexofenadine

C32H39NO4

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

In another aspect, the present invention provides a process for preparing crystalline fexofenadine hydrochloride Form XVI comprising the steps of combining a solution of HCl in a mixture of methanol and isopropyl alcohol, with fexofenadine base, to obtain a solution, evaporating the methanol and the isopropyl alcohol to obtain a residue, adding a mixture of methanol and heptane to the residue to precipitate crystalline fexofenadine hydrochloride and recovering the fexofenadine hydrochloride.

WORKUP

后处理

customIn another aspect, the present invention provides a process

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d6b009adde0849b0aea62c9ca3b8c411
来源数据集: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07671071B2
来源说明: uspto-grants-2010_03

反应 SMILES

[CH3:1][C:2]([C:35]([OH:37])=[O:36])([C:4]1[CH:5]=[CH:6][C:7]([CH:10]([OH:34])[CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([C:20]([OH:33])([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH2:16][CH2:15]2)=[CH:8][CH:9]=1)[CH3:3].Cl.Cl>CO.C(O)(C)C>[CH3:3][C:2]([C:35]([OH:37])=[O:36])([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([OH:34])[CH2:11][CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][CH:17]([C:20]([OH:33])([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH2:18][CH2:19]2)=[CH:6][CH:5]=1)[CH3:1]