Methanesulfonic Acid → N-[(amino-4-methoxybenzylamino)-methylene]-4-methylbenzene-sulfonamide

HRID 2242152Notes

Reaction equation

HRID 2242152 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5](C)[N:4]([C:8](=N)[NH:9][S:10]([C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)(=[O:12])=[O:11])[N:3]=1.CS(O)(=O)=O.[CH3:26][O:27][C:28]1C=CC(CN)=[CH:30][CH:29]=1>>[NH2:3][N:4]([CH:8]=[N:9][S:10]([C:13]1[CH:14]=[CH:15][C:16]([CH3:19])=[CH:17][CH:18]=1)(=[O:11])=[O:12])[CH2:5][C:6]1[CH:2]=[CH:1][C:28]([O:27][CH3:26])=[CH:29][CH:30]=1

Participants

4

Reactant 3

HCID 6395Methanesulfonic AcidHCID 754524-MethoxybenzylamineHCID 178427489N-[(3,5-dimethylpyrazol-1-yl)-iminomethyl]-4-methylbenzene-sulfonamide

Product 1

HCID 67176632N-[(amino-4-methoxybenzylamino)-methylene]-4-methylbenzene-sulfonamide

Procedure

The compound of Example 6 was prepared according to the accompanying synthesis procedure from 0.5 ml of N-[(3,5-dimethylpyrazol-1-yl)-iminomethyl]-4-methylbenzene-sulfonamide solution (0.2 M, acetonitrile) with 19 mg of methanesulfonic acid and 0.5 ml of 4-methoxybenzylamine solution (1.0 M, acetonitrile) and filed in a substance databank. Calculated mol. wt. 333.41; found mol. wt. (M+H) 334.2; 667.0 (Dimer)

Sources & evidence

ORD record
ord-b5ec828d31634012853f5903964b717a
Source dataset
uspto-grants-2010_03
Patent number
US07671074B2

Reaction notes

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