Hydrochloric Acid → HCID 136338384, compound

HRID 2242175Notes

Reaction equation

HRID 2242175 reaction equation
C([O:3][C:4](=[O:21])[CH2:5][N:6]1[C:10]2[C:11]3[CH:12]=[C:13]([CH3:20])[CH:14]=[CH:15][C:16]=3[O:17][C:18](=[O:19])[C:9]=2[CH:8]=[N:7]1)C.[Li+].[OH-:23].Cl>C1COCC1>[C:4]([CH2:5][N:6]1[C:10]([C:11]2[CH:12]=[C:13]([CH3:20])[CH:14]=[CH:15][C:16]=2[OH:23])=[C:9]([C:18]([OH:17])=[O:19])[CH:8]=[N:7]1)([OH:3])=[O:21]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 22334559HCID 22334559, compound

Product 1

HCID 136338384HCID 136338384, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of (8-Methyl-4-oxo-4H-chromeno[4,3-C]pyrazol-1-yl)-acetic acid ethyl ester g (1 mmol, 286 mg) in THF (4 mL) was added 1M aq. LiOH (2 mL, 2 mmol) was added and the resultant mixture was stirred for 2 h at rt. The reaction mixture was neutralized with 1N HCl, and concentrated in vacuo to remove THF. The crude residue was extracted with ethyl acetate (3×20 mL). The combined organic extracts were dried over Na2SO4, and concentrated to provide the desired product h that is used without further purification.

Workup

  1. additionwas added
  2. concentrationconcentrated in vacuo
  3. customto remove THF
  4. extractionThe crude residue was extracted with ethyl acetate (3×20 mL)
  5. dry with materialThe combined organic extracts were dried over Na2SO4
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-e5407d289b164d43a4e3ef02845935aa
Source dataset
uspto-grants-2010_03
Patent number
US07671069B2

Reaction notes

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